Method for detecting a mammal's prior exposure to radiation or radiomimetic chemicals
AssigneeThe Research Foundation of State University of New York
InventorsJoseph K. Gong, Chester A. Glomski
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Abstract
The present invention is directed to a method for detecting a mammal's prior exposure to radiation or radiomimetic agents. Labeled antibodies are employed to determine the quantity of transferrin receptors on the red blood cells of the mammal. The quantity of transferrin receptors on the red blood cells of the mammal is correlated to the mammal's prior exposure.
Claims21
A method for detecting a mammal's prior exposure to radiation or radiomimetic agents comprising:
- providing a sample of red blood cells from a mammal, wherein the red blood cells comprise a transferrin receptor on the surface thereof whose quantity increases with increasing exposure of the mammal to radiation or radiomimetic agents beyond a baseline quantity of transferrin receptor on the surface of red blood cells that have not been exposed to radiation or radiomimetic agents;
- detecting the quantity of the transferrin receptor on the red blood cells;
- and
- correlating the quantity of the transferrin receptor on the red blood cells to the mammal's prior exposure to radiation or radiomimetic agents.
A method for detecting a mammal's prior exposure to radiation or radiomimetic agents comprising:
- providing a sample of red blood cells from a mammal, wherein the red blood cells have a quantity of a transferrin receptor on the surface thereof encoded by a nucleotide sequence within a DNA locus, which locus contains a gene encoding the transferrin receptor wherein the quantity of transferrin receptor is in excess of an arbitrary baseline;
- detecting the quantity of said protein on the red blood cells of the sample;
- and
- correlating the quantity of the protein on the red blood cells to the mammal's prior exposure to radiation or radiomimetic agents.
A method for detecting a mammal's prior exposure to radiation or radiomimetic agents comprising:
- providing a sample of red blood cells from a mammal, wherein the red blood cells have a quantity of transferrin receptors on the surface thereof in excess of an arbitrary baseline;
- detecting the quantity of transferrin receptors on the red blood cells;
- and
- correlating the quantity of transferrin receptors on the red blood cells to the mammal's prior exposure to radiation or radiomimetic agents.
Dependencies are inferred from the claim text.