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US 5,691,147 AGranted
CDK4 binding assay
AssigneeMitotix, Inc.
InventorsGiulio Draetta, Jeno Gyuris
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Abstract
The present invention relates to the discovery of novel proteins of mammalian origin which can associate with the human cyclin dependent kinase 4 (CDK4).
Claims1
An assay for screening test compounds for an inhibitor of an interaction of a cyclin dependent kinase (CDK) with a CDK4-binding protein (CDK-BP) comprising
- i. combining a CDK and a CDK4-BP comprising an amino acid sequence selected from a group consisting of SEQ ID Nos. 25-48, under conditions wherein said CDK and said CDK4-BP are able to interact;
- ii. contacting said combination with a test compound;
- and
- iii. detecting the formation of a complex comprising said CDK and said CDK4-BP,
- wherein a decrease in the formation of said complex in the presence of said test compound is indicative of an inhibitor of the interaction between said CDK and said CDK4-binding protein.
2 more elements
Dependencies are inferred from the claim text.