Method for inactivating pathogens in red cell compositions using quinacrine mustard
AssigneeCerus Corporation
InventorsSusan Wollowitz, David Cook, Aileen Nerio
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Abstract
Methods and compositions for treating pathogens in material are described, including methods of decontaminating human fluids prior to processing in the clinical laboratory and methods for decontaminating blood products prior to in vivo use. The techniques handle large volumes of human serum without impairing the testing results. Novel compounds for photodecontaminating biological material are also contemplated which are compatible with clinical testing, in that they do not interfere with serum analytes. In particular, quinacrine mustard is used to inactivate pathogens in red cell compositions with retention of red cell function.
Claims7
A method of inactivating pathogens in a red blood cell containing composition, comprising:
- a) adding N1,N1-bis(2-chloroethyl)-N4-(6-chloro-2-methoxy-9-acridinyl)-1,4-pentanedi amine to a blood product comprising red blood cells, where said blood product is suspected of containing pathogens, to create a mixture, said N1,N1-bis(2-chloroethyl)-N4-(6-chloro-2-methoxy-9-acridinyl)-1,4-pentanedi amine reaching a final concentration of N1,N1-bis(2-chloroethyl)-N4-(6-chloro-2-methoxy-9-acridinyl)-1,4-pentanedi amine of between 1 .mu.g/ml and 250 .mu.g/ml, and
- b) incubating said mixture in vitro for between 1 minute and 48 hours.
Dependencies are inferred from the claim text.