Acidic polysaccharides crosslinked with polycarboxylic acids and their uses
AssigneeHercules Incorporated
InventorTuyen T. Nguyen
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Abstract
Acidic polysaccharides crosslinked by reaction with di- or polyanhydrides. The use of anhydride-crosslinked hyaluronic acid as a treatment for arthritis, as a drug delivery vehicle, to reduce the incidence of post-operative adhesion formation, to promote the healing of chronic wounds and ulcers, and as a component of cosmetic formulations.
Claims4
A crosslinked composition comprising linked hyaluronic acid or salts thereof wherein at least one hydroxyl group of each linked hyaluronic acid or salt thereof is esterified with a carboxyl group contained in a monomeric polycarboxylic acid having at least four carboxyl groups, wherein at least two carboxyl groups of the polycarboxylic acid are esterified with hydroxyl groups of the polysaccharides, and wherein said crosslinked composition has substantially greater resistance to the enzyme hyaluronidase or to hydroxyl radicals than does hyaluronic acid or salts thereof.
Dependencies are inferred from the claim text.