Back to results
US 5,690,959 AGranted
Pharmaceutical thermal infusion process
AssigneeSmithKline Beecham Corporation
InventorsNageswara R. Palepu, Gopadi M. Venkatesh
Life of this patent
Estimating the term…
Abstract
A chewable tablet comprises a medicament dispersed in a chewable base, such as mannitol, together with an effervescent couple, such as citric acid--sodium bicarbonate. The combination of effervescence and chewability with optional flavorings improves the taste characteristics of the medicament in oral administration. A distintegrant such as microcrystalline cellulose may be added to give the patient the option of dispersing the tablet in water.
Claims34
A process for preparing controlled release solid dosage forms of pharmaceutically active materials which comprises:
- (a) blending a pharmaceutically active material, a hydrophobic waxy material and optional additives;
- (b) compacting, milling and screening said blend;
- and
- (c) thermally infusing the screened blend in a granulator at a thermal infusion temperature to yield thermal infusion granules.
1 more element
Dependencies are inferred from the claim text.