Prostaglandin derivatives
AssigneeOno Pharmaceutical Co., Ltd.
InventorsAkio Nishiura, Takuya Seko, Ryoji Matsumoto, Shin-ichi Hamano
Life of this patent
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Abstract
Prostaglandin E, ester derivatives of the formula (I): ##STR1## wherein R is (i) --CH.sub.2 CH.sub.2 --O--CO--R.sup.1 (ii) --CH.sub.2 CH.sub.2 --O--CO--CH.sub.2 --O--R.sup.2, and R.sup.1 and R.sup.2 each independently is C10-20 alkyl; and cyclodextrin clathrates thereof, liposome formulations containing them, and pharmaceutical compositions containing them as active ingredient. The compounds of formula (I) have the effect of increasing blood flow and are useful for the prevention and/or treatment of peripheral circulatory disorder, decubitus, or skin ulcers, or for the maintenance of blood flow.
Claims12
A prostaglandin E.sub.1 ester derivative of formula (1):
- ##STR18## wherein R is (i) --CH.sub.2 CH.sub.2 --O--CO--R.sup.1, or
- (ii) --CH.sub.2 CH.sub.2 --O--CO--CH.sub.2 --O--R.sup.2, and
- R.sup.1 and R.sup.2 each independently is C10-20 alkyl;
- or a cyclodextrin clathrate thereof.
Dependencies are inferred from the claim text.