Storage of parenterally administerable products
AssigneePharmacia & Upjohn Aktiebolag
InventorsYves Bourboulou, Micheline Boucheteil, Celine Philippon, Jean Tronchet
Life of this patent
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Abstract
The present invention is directed to the method and use of a helium containing gas for improving the physical stability of packaged sensitive products, especially those products which contain a fat emulsion.
Claims21
Method of increasing the physical stability of a product for parenteral administration comprising a lipid emulsion packaged in an at least partially gas permeable container which comprise storing said lipid emulsion in an inert gas consisting essentially of helium.
A method of manufacturing a package for improving the physical stability of a parenteral product comprising a lipid emulsion which comprises packaging said parenteral product in a partially gas permeable container to provide a packaged product;
- thereafter placing the packaged product in a substantially airtight envelope;
- then removing environmental air from said envelope by drawing a vacuum;
- then restoring atmospheric pressure by supplying an inert gas consisting essentially of helium and then sealing said envelope.
A packaged parenteral product exhibiting improved physical stability during long-term storage which comprises a parenteral product comprising a lipid emulsion packaged in a partially gas permeable container and sealed in a substantially airtight envelope containing an inert gas consisting essentially of helium and being free of environmental air.
Dependencies are inferred from the claim text.