Adjuvants for viral vaccines
AssigneeAmerican Home Products Corporation
InventorRichard N. Hjorth
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Abstract
The present invention discloses mammalian vaccine compositions having an effective amount of an adjuvant, the adjuvant comprising squalene or squlane, one or more phospholipids and a surfactant. These compositions also optionally contain an aluminum salt and one or more pharmaceutically acceptable buffers.
Claims10
A mammalian vaccine composition comprising an inactivated whole or subunit vaccine and an effective amount of an adjuvant, the adjuvant consisting essentially of any one of squalene, squalane, or a mixture thereof, in the amount of from about 1% to about 40% by volume of the total composition, a lecithin in the amount of from about 0.5% to about 4% by volume of the total composition, and a polyoxyethylenesorbitan ester surfactant in the amount of from about 0.1% to about 4.0% of the total composition.
A mammalian vaccine composition comprising an inactivated whole or subunit vaccine and an effective amount of an adjuvant in a pharmaceutically acceptable buffer, the adjuvant consisting essentially of squalene in the amount of from about 8% to about 12% by volume of the total composition, a lecithin in the amount of from about 0.8% to about 1.2% by volume of the total composition, and a polyoxyethylenesorbitan ester surfactant in the amount of from about 0.18% to about 0.22% of the total composition, the composition further containing from about 0.1% to about 2.0% of an aluminum salt.
Dependencies are inferred from the claim text.