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US 5,690,937 AGranted
Temperature sensitive clustered changed-to-alanine mutants of influenza virus PB2 gene
AssigneeAviron
InventorsNeil T. Parkin, Kathleen L. Coelingh
Life of this patent
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Abstract
Recombinant PB2 variant influenza viruses, RNA, cDNA and vectors are provided. Also provided are immunogenic compositions containing the variant viruses, methods of producing such viruses and methods for the prophylactic treatment of influenza in humans.
Claims4
A recombinant RNA sequence encoding an influenza PB2 protein, wherein said RNA sequence comprises a mutation selected from the group consisting of the mutations set forth as ALA1, ALA4, ALA6, ALA7 and ALA8.
Dependencies are inferred from the claim text.