Monoclonal antibodies for inducing tolerance
AssigneeGlaxo Wellcome Inc.
InventorsStephen Paul Cobbold, Herman Waldmann
Life of this patent
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Abstract
Tolerance to an antigen is induced in a subject by administering a non-depleting CD4 monoclonal antibody and a non-depleting CD8 monoclonal antibody. Tolerance to the antigen can be induced under cover of these antibodies. A depleting CD4 monoclonal antibody and/or a depicting CD8 monoclonal antibody may be administered prior to the non-depleting antibodies.
Claims4
A method of treating in a human a disorder mediated by an immune reaction to a self-antigen, said method comprising administering to a human in need of said treatment an amount of a non-depleting anti-CD4 monoclonal antibody as the whole antibody sufficient to induce long-term specific immunological unresponsiveness to said self-antigen thereby effecting said treatment.
Dependencies are inferred from the claim text.