Method for treating thromboembolic conditions via the use of multiple bolus administration of thrombolytically active proteins
AssigneeBoehringer Mannheim GmbH
InventorsUlrich Martin, Reinhard Konig
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Abstract
Discussed are therapeutic approaches to the treatment of thrombolic conditions. The therapies use thrombolytically active proteins which function by, e.g., inhibiting reocclusion in the subject. The proteins are administered in two or more boli.
Claims20
Method for treatment of a thromboembolic condition comprising administering to a subject with a thromboembolic condition a thrombolytically effective amount of a thrombolytically active protein which has a half life greater than recombinant human t-PA, in the form of at least two boli over a twenty four hour period, wherein the second bolus contains an amount of thrombolytically active protein which is less than or equal to the amount of thrombolytically active protein in the first bolus.
Dependencies are inferred from the claim text.