Use of methioninase and chemotherapy agents in chemotherapy
AssigneeAntiCancer, Inc.
InventorsValeryi Lishko, Yuying Tan, Qinghong Han, Mingxu Xu, Huiyan Guo
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Abstract
The present invention describes methods for using methioninase as an antitumor reagent in anti-methionine chemotherapy. Specifically, methioninase is used to slow or stop cell division which can be enhanced with competitive inhibitors of methionine. In addition, methioninase can be used in combination with chemotherapeutic agents to increase the therapeutic effectiveness of the agent by inducing cell cycle synchronization.
Claims10
A method for inducing tumor cell death in vivo comprising the step of contacting a population of tumor cells in vivo with a therapeutically effective amount of a methioninase composition, said methioninase having a K.sub.m of about 1 mM or less, a specific activity of at least about 16 units per mg protein and less than about 10 ng endotoxin per mg protein in combination with a chemotherapeutic agent.
Dependencies are inferred from the claim text.