Use of neuro-glial fetal cell lines for transplantation therapy
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsEugene O. Major, Carlo S. Tornatore, Kris Bankiewicz
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Abstract
Human fetal neuro-derived cell lines are implanted into host tissues. The methods allow for treatment of a variety of neurological disorders and other diseases. A preferred cell line is SVG.
Claims21
A method for treating a mammal having a neurological syndrome or disease characterized by a dopamine deficiency comprising implanting into said mammal a therapeutically effective amount of a nontumorigenic and noninflammatory immortalized human neuro-glial cell line capable of inducing neuromigration and/or neurite extension in the mammal.
A method for treating Parkinson's Disease in a mammal comprising implanting a therapeutically effective amount of a suspension of an immortalized human neuro-glial cell line having a 10.sup.4 -10.sup.7 cell density into the basal ganglia of the mammal, wherein the glial cells are characterized as nontumorigenic, noninflammatory in the recipient mammal, and capable of inducing neuromigration and/or neurite extension in the mammal.
A method of treating a neurological disorder characterized by a dopamine deficiency caused by a lesion in a mammal's central nervous system, comprising:
- placing a needle into the central nervous system of the recipient mammal;
- and injecting a therapeutically effective amount of a suspension of nontumorgenic, noninflammatory and immortalized human neuro-glial cell line into the central nervous system through the needle, wherein the cell line is capable of inducing neuromigration and/or neurite extension in the mammal.
Dependencies are inferred from the claim text.