Recombinant gamma interferons having enhanced stability and methods therefor
AssigneeGenentech, Inc.
InventorsPatrick W. Gray, Ernst H. Rinderknecht
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Abstract
The present invention relates to novel, stable recombinant gamma interferons exhibiting in greater or less degree the antiviral and antiproliferative activity in humans and pH 2 labile properties characteristic of native human gamma interferon. The amino acid sequence of such an interferon comprises, from the N-terminus: ##STR1## wherein X is a methionine residue or hydrogen and Y is a glutamine residue or, where X is hydrogen, Y is either a glutamine or a pyroglutamate residue.
Claims9
A polypeptide exhibiting the characteristic properties of native human gamma interferon and consisting of the amino acid sequence, extending from the N-terminus:
- ##STR6## wherein X is a methionine residue or hydrogen and Y is a glutamine residue or where X is hydrogen, Y is either a glutamine or a pyroglutamate residue, and Z is ##STR7##
A composition comprising a mixture of the polypeptides:
- 1) the polypeptide having the amino acid sequence:
- ##STR8## and 2) the polypeptide having the amino acid sequence:
- ##STR9## or when X is methionine, ##STR10## wherein X is a methionine residue or hydrogen and Y is a glutamine residue or where X is hydrogen, Y is either a glutamine or a pyroglutamate residue.
A composition comprising a mixture of the polypeptides:
- 1) the polypeptide having the amino acid sequence:
- ##STR11## wherein X is methionine and 2) the polypeptide having the amino acid sequence:
- ##STR12## wherein X is methionine.
Dependencies are inferred from the claim text.