Stable topical retinoid compositions
AssigneeYamanouchi Europe B.V.
InventorsTom DeVringer, Antoon Van Harrewijn, Aart Muehlenbruch
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Abstract
Compositions for topical application to the skin are provided, which compositions comprise a retinoid in an aqueous vehicle, and further contain at least one non-ionic surfactant, wherein the non-ionic surfactant is the crystallization-preventing and stabilizing agent for said retinoid and is selected from the group consisting of polyoxyethylene mono fatty alcohol ethers, polyoxyethylene glyceryl fatty acid triesters and ethyleneoxide/propyleneoxide block copolymers.
Claims8
A composition for topical application to the skin comprising a retinoid in an aqueous vehicle said aqueous vehicle further comprising up to 5 wt % of an organic solvent, and at least one non-ionic surfactant wherein the aqueous vehicle has a pH of between 3 and 7 and the non-ionic surfactant is a crystallization preventing and stabilizing agent for said retinoid and is selected from the group consisting of
- a) polyoxyethylene mono fatty alcohol ethers,
- b) polyoxyethylene glyceryl fatty acid triesters, and
- c) ethylene oxide/proclaim oxide block copolymers.
Composition according to claim 4 wherein the polyoxyethylene glycerin fatty acid monoester is polyoxyethylene (15) glycerin monolaurate.
Dependencies are inferred from the claim text.