Diagnostic radiopharmaceutical compounds (That)
AssigneeAmersham International plc
InventorsSusan E. MacWhorter, Tiann-long Wu, Douglas S. White
Life of this patent
Estimating the term…
Abstract
Tetradentate ligands are used to form neutral 99m-technetium complexes which may be useful as radiopharmaceuticals e.g. as brain imaging agents. The ligands have the structure ##STR1## where n is 2 or 3, m is 0-4, R is H or substituted or unsubstituted C.sub.1 -C.sub.6 alkyl, provided that one CR.sub.2 group adjacent the starred nitrogen atom represents CO and forms with the adjacent N atom, a --CONH-- amide group, Y is unsubstituted or substituted C.sub.1 -C.sub.6 alkyl, and one of X and X' represents H or a labile thiol protecting group while the other is unsubstituted or substituted C.sub.1 -C.sub.6 alkyl, alkenyl or alkynyl.
Claims6
A neutral .sup.99m Tc complex of the structure:
- ##STR13## where n is 2 or 3;
- m is 0 to 4;
- one CR.sub.2 group adjacent the starred nitrogen atom represents CO and forms, together with the adjacent N atom, a --CONH--amide group, other groups R are the same or different at different places in the molecule, and each is H or C.sub.1 to C.sub.6 alkyl;
- Y is the same or different at different places in the molecule and each is C.sub.1 -C.sub.4 alkyl, alkoxyalkyl, alkoxy, amino, isothiocyanate or acyloxy;
- each of X and X' is C.sub.1 -C.sub.6 alkyl, alkenyl, alkynyl, hydroxyalkyl, alkoxyalkyl, aminoalkyl, carboxyalkyl, acyloxyalkyl, aminoalkyl, haloalkyl of nitriloalkyl.
Dependencies are inferred from the claim text.