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US 5,689,002 AGranted
Process for the crystallization from water of (S)-N,N'-bis2-hydroxy-1-(hydroxymethyl)ethyl!-5-2-hydroxy-1-oxopropyl) amino!-2,4,6-triiodo-1,3-benzendicarboxamide
AssigneeBracco International B.V.
InventorMarina Mauro
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Abstract
This invention refers to a process for the crystallization from water of S-N,N'-bis2-hydroxy-1(hydroxymethyl)ethyl!-5-(2-hydroxy-1-oxopropyl)amin o!-2,4,6-triiodo-1,3-benzendicarboxamide known as Iopamidol. According to the process of this invention, a crystalline anhydrous Iopamidol in accordance with pharmacopeia standards can be obtained.
Claims8
A process for the crystallization from water of Iopamidol to give said compound in a crystalline anhydrous form and in accordance to the pharmacopeia standards comprising the following steps:
- dissolution of Iopamidol in deionized water by heating;
- decolorisation of the solution with active carbon;
- vacuum-concentration of the aqueous solution at 60.degree. C.;
- addition of crystalline germs of anhydrous Iopamidol for seeding the crystallization;
- crystallization at 60.degree. C.;
- filtration of the resulting precipitate;
- vacuum-drying of the wet product.
4 more elements
Dependencies are inferred from the claim text.