Tricyclic aminoalkylcarboxamides; novel dopamine D.sub.3 receptor subtype specific ligands
AssigneeNeurogen Corporation
InventorsXi Chen, Jun Yuan, Andrew Thurkauf
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AssigneeNeurogen Corporation
InventorsXi Chen, Jun Yuan, Andrew Thurkauf
Estimating the term…
Disclosed are compounds of the formula: ##STR1## or the pharmaceutically acceptable acid addition salts thereof wherein: R1-R.sub.4 represent organic or inorganic groups; A represents an alkylene group of 2 to 6 carbon atoms optionally substituted with one or more alkyl groups having from 1 to 4 carbon atoms; Y represents methylene, oxygen, sulfur, or NH; and X is either N, C or CH, which compounds are useful in the treatment of affective disorders such as schizophrenia, depression, Alzheimer's disease, movement disorders such as Parkinsonism and dystonia, and other disorders which respond to dopaminergic blockade such as substance abuse and obsessive compulsive disorders. Further, compounds of this invention may be useful in treating the extrapyramidal side effects associated with the use of conventional neuroleptic agents.
A compound of the formula:
A compound of the formula:
Dependencies are inferred from the claim text.