Pyrazolo›1,5-A!pyrimidine derivatives and anti-inflammatory agent containing the same

A pyrazolo ›1,5-a!pyrimidine derivative of the general formula:

• ##STR57## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are the same or different and are each a hydrogen atom, a phenyl group, a lower alkyl group which may optionally be substituted by a hydroxyl group, or a cycloalkyl group, or R.sub.1 and R.sub.2 may combine with each other to form a lower alkylene group;
• R.sub.5 is a group of the formula:
• --SR.sub.6 or a group of the formula:
• --NR.sub.7 R.sub.8 in which R.sub.6 is a pyridyl group or a phenyl group which may optionally be substituted by 1 to 3 groups selected from a hydroxyl group and a lower alkyl group;
• and R.sub.7 and R.sub.8 are a hydrogen atom or a phenyl group which may optionally be substituted by 1 to 3 groups selected from a hydroxyl group, a lower alkyl group, a lower alkoxycarbonyl group and carboxyl group, provided that R.sub.7 and R.sub.8 are not simultaneously hydrogen atoms, or R.sub.7 and R.sub.8 may combine with each other to form with a nitrogen atom with which they bond 1-pyrrolidinyl group, 2-oxo-1-pyrrolidinyl group, or 1-piperazinyl group substituted by a member selected from the group consisting of a phenyl group having optionally a halogen- or trihalomethyl-substituent, a hydroxy-lower alkyl group or a diphenyl-lower alkyl group, or a salt thereof.