Loading patent…
AssigneesThe Brigham and Women's Hospital, Inc., NPS Pharmaceuticals, Inc.
InventorsEdward M. Brown, Forrest H. Fuller, Steven C. Hebert, James E. Garrett, Jr.
Estimating the term…
The present invention relates to the different roles inorganic ion receptors have in cellular and body processes. The present invention features: (1) molecules which can modulate one or more inorganic ion receptor activities, preferably the molecule can mimic or block an effect of an extracellular ion on a cell having an inorganic ion receptor, more preferably the extracellular ion is Ca.sup.2+ and the effect is on a cell having a calcium receptor; (2) inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (3) nucleic acids encoding inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (4) antibodies and fragments thereof, targeted to inorganic ion receptor proteins, preferably calcium receptor protein; and (5) uses of such molecules, proteins, nucleic acids and antibodies.
A purified nucleic acid comprising at least 20 contiguous nucleotides of a nucleic acid sequence provided in SEQ ID NO:
A purified nucleic acid comprising a nucleic acid sequence encoding at least 12 contiguous amino acids of an amino acid sequence provided in SEQ ID NO:
A purified nucleic acid comprising a nucleotide sequence which comprises at least 16 nucleotides hybridizing under stringent conditions to at least 20 contiguous nucleotides provided in SEQ ID NO:1.
A purified nucleic acid comprising a nucleotide sequence which comprises at least 18 nucleotides hybridizing under stringent conditions to at least 20 continuous nucleotides provided in SEQ ID NO:1.
A purified nucleic acid comprising a nucleotide sequence which comprises at least 19 nucleotides hybridizing under stringent conditions to at least 20 contiguous nucleotides provided in SEQ ID NO:1.
A purified nucleic acid comprising a nucleotide sequence which comprises at least 20 nucleotides hybridizing under stringent conditions to at least 20 contiguous nucleotides provided in SEQ ID NO:1.
A purified nucleic acid comprising a nucleic acid sequence selected from the consisting of:
A purified nucleic acid comprising a nucleic acid sequence encoding an amine acid sequence selected from the group consisting of SEQ ID NO:
Dependencies are inferred from the claim text.