Vesicle membrane transport proteins
AssigneeThe Regents of the University of California
InventorRobert H. Edwards
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Abstract
Complete cDNA and amino acid sequences are disclosed for rat adrenal-specific and brain-specific transport protein, as well as for human brain-specific transport protein. Methods for obtaining the genes encoding these proteins and for obtaining recombinantly produced protein are described. Antibodies and methods for isolating additional vesicle membrane transport proteins are also described. Methods for using the vesicle membrane transport proteins to identify compounds that selectively inhibit transport of toxic molecules into vesicles, and that prevent inhibition of transport of toxic molecules are also provided. The invention includes methods to treat and diagnose diseases associated with sequestration of toxic molecules in mammalian cells.
Claims1
An isolated DNA molecule encoding the amino acid sequence shown in FIG. 1 (SEQ ID NO:
- 2).
Dependencies are inferred from the claim text.