Preparation of biologically active compounds from substantially pure enantiomers of 2-azabicyclo2.2.1!hept-5-en-one
AssigneeChiroscience Limited
InventorsChristopher Thomas Evans, Stanley Micahel Roberts
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Abstract
Lactams of 1-amino-3-carboxylic acid cyclic compounds are provided in enantiomeric form, together with an enantiomer of the corresponding ring-opened amino-acid or ester, by reaction of the racemic lactam with a novel lactamase. The products are useful in the synthesis of chiral carbocyclic nucleotides. The enantiomer is preferably 2-azabicyclo2.2.1!hept-5-en-3-one.
Claims24
In a process for producing a substantially pure enantiomer of a compound having biological activity, the process comprising at least one step of reacting racemic or slightly resolved 2-azabicyclo2.2.1!hept-5-en-3-one to form another racemic or slightly resolved intermediate or product,
- the improvement wherein a substantially pure enantiomer of 2-azabicyclo2.2.1!hept-5-en-3-one is used instead of the racemic or slightly resolved 2-azabicyclo2.2.1!hept-5-en-3-one, whereby a substantially pure enantiomer of the compound having biological activity is produced.
Dependencies are inferred from the claim text.