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US 5,688,921 AGranted
Reagents and methods for the detection and qualification of thyroxine in fluid samples
AssigneeAbbott Laboratories D-337/AP6D
InventorsMaciej Adamczyk, Donald D. Johnson, Phillip G. Mattingly, Diana E. Clarisse, Joan D. Tyner, Mary M. Perkowitz
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Abstract
Immunoassay methods and reagents for the specific quantification of thyroxine in a test sample are disclosed employing antibodies prepared with thyroxine derivatives of the formula: ##STR1## wherein P is an immunogenic carrier material and X is a linking moiety. The present invention also describes the synthesis of unique labelled reagent of the formula: ##STR2## wherein Q is a detectable moiety and W is a linking moiety, preferably fluorescein or a fluorescein derivative.
Claims2
An immunogen of the formula:
- ##STR10## wherein BSA denotes bovine serum albumin, the degree of substitution of BSA by the thyroxine derivative is between 1% to 100% thyroxine is L-isomer, and wherein antibodies directed against the immunogen immunoreact with a thyroxine conjugate of the formula:
- ##STR11## where Q is a detectable moiety and W is a linking moiety.
Dependencies are inferred from the claim text.