Trk neurotrophin binding motifs
OwnerRainer Schneider, Jorg M. Windischinventors
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Abstract
Trk neurotrophin binding motifs consisting of 24 amino acid, leucine rich domains are described as well as nucleic acid sequences encoding such peptides. The leucine rich motifs are useful in screens for novel agonists and antagonists of the neurotrophins.
Claims6
Isolated and purified leucine rich motif (LRM.sub.2) of the TrkA receptor having a sequence selected from the group consisting of the following sequences:
- a) T I V K S G L R F V A P D A F H F T P R L S R L (SEQ ID NO:1);
- and
- b) T I V K S G L R F V A P D A F H F T P R L S H L (SEQ ID. NO:
- 4).
Isolated and purified leucine rich motif (LRM.sub.2) of the TrkB receptor having a sequence selected from the group consisting of the following sequences:
- a) T I V D S G L K F V A H K A F L K N S N L Q H I (SEQ ID NO:2);
- and
- b) T I V D S G L K F V A Y K A F L K N G N L R H I (SEQ ID NO:
- 5).
Isolated and purified leucine rich motif (LRM.sub.2) of the TrkC receptor having the following sequence:
- a) T I K N S G L R S I Q P R A F A K N P H L R Y I (SEQ ID NO:3).
Dependencies are inferred from the claim text.