Therapeutic injectable analgesic composition containing nimesulide and a process for the manufacture thereof
AssigneePanacea Biotec Limited
InventorsRajesh Jain, Amarjit Singh
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Abstract
Therapeutic injectable analgesic pharmaceutical compositions for intramuscular administration containing nimesulide. The pharmaceutical compositions comprise nimesulide, dimethylacetamide, benzyl benzoate and ethyl oleate.
Claims16
A therapeutic injectable analgesic pharmaceutical composition for intra-muscular administration comprising:
- ______________________________________ Nimesulide 2.5% to 10% w/v and Parenteral absorption 90% to 97.5% w/v enhancing vehicle base ______________________________________
- wherein said parenteral absorption enhancing base comprises;
- ______________________________________ Dimethylacetamide 5% to 12% w/w, Benzyl benzoate 20% to 50% w/v and Ethyl oleate 30% to 65% w/v. ______________________________________
A process for the preparation of a therapeutic injectable analgesic composition containing nimesulide for intra-muscular administration which comprises:
- (a) mixing 5% to 12% w/v of dimethylacetamide and 20% to 50% w/v of benzyl benzoate and adding 3% to 7% w/v of Nimesulide and stirring until completely dissolved;
- (b) mixing separately up to 10% w/v of Benzyl alcohol and a portion of 30% to 65% w/v of ethyl oleate;
- and
- (c) adding the mixture obtained in step (a) to the mixture obtained in step (b) under slow stirring.
A process for the preparation of a therapeutic injectable analgesic composition containing nimesulide for intra-muscular administration which comprises:
- (a) mixing 5% to 12% w/v of Dimethylacetamide and 20% to 50% w/v of Benzyl benzoate and adding 3% to 7% w/v of Nimesulide and stirring until completely dissolved;
- (b) adding 30% to 65% w/v of Ethyl oleate to the mixture obtained in step (a) under slow stirring.
Dependencies are inferred from the claim text.