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AssigneeAmerican Home Products Corporation
InventorKenneth Lewis Kees
Estimating the term…
This invention relates to compounds of the formula ##STR1## where R.sup.1 and R.sup.2 are both hydrogen or R.sup.1 and R.sup.2 form a bond; m=1 and n=3 and p=6, or m=3, 5 or 7 and n=1 and p=6, or m=4 and n=2 and p=6 or 8, and the E (trans) and Z (cis) isomers when R.sup.1 =R.sup.2 =H; and the basic addition salts thereof which are inhibitors of phospholipase A.sub.2 and are thus useful agents in the treatment of inflammatory diseases where arachidonic acid metabolic products are implicated, such as rheumatoid arthritis, inflammatory bowel diseases such as ulcerative colitis, atopic dermatitis conditions such as psoriasis and immediate hypersensitivity reactions such as allergic bronchial asthma and allergic rhinitis; and as gastric cytoprotective agents.
A compound having the formula ##STR6## where R.sup.1 and R.sup.2 are both hydrogen or R.sup.1 and R.sup.2 form a bond;
A method of treating inflammatory diseases mediated by arachidonic acid metabolites which comprises administering to a mammal needing such treatment a phospholipase A.sub.2 -inhibiting amount of a compound having the formula ##STR7## where R.sup.1 and R.sup.2 are both hydrogen or R.sup.1 and R.sup.2 form a bond;
A pharmaceutical composition which comprises a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of the formula ##STR8## where R.sup.1 and R.sup.2 are both hydrogen or R.sup.1 and R.sup.2 form a bond;
Dependencies are inferred from the claim text.