Di(aromatic) compounds and their use in human and veterinary medicine and in cosmetics
AssigneeCentre Int'l. De Recherches Dermatologiques Galderma
InventorsJean-Michel Bernardon, William Robert Pilgrim
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Abstract
Di(aromatic) compounds corresponding to the following formula: ##STR1## in which: Ar represents either ##STR2## n=1 or 2 or: ##STR3## X represents a divalent radical, Z represents O, S or a divalent radical, and R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 represent a hydrogen atom or various organic radicals, and the salts of the compounds of formula (I) when R.sub.1 is a carboxylic acid function. Use in human and veterinary medicine and in cosmetics.
Claims20
A di(aromatic) compound having the formula ##STR15## wherein Ar represents ##STR16## wherein n=1 or 2 or ##STR17## wherein R.sub.3 and R.sub.5 represent hydrogen, OH, alkoxy having 1-6 carbon atoms, .alpha.-branched alkyl having from 3-12 carbon atoms, .alpha.,.alpha.-branched alkyl having from 4-12 carbon atoms, cycloalkyl having 3-12 carbon atoms, or mono- or polycyclic cycloalkyl having 5-12 carbon atoms in which the carbon having the free valence is trisubstituted,
- R.sub.4 represents alkoxy having 1-6 carbon atoms, .alpha.-branched alkyl having 3-12 carbon atoms, .alpha.,.alpha.-branched alkyl having 4-12 carbon atoms, cycloalkyl having 3-12 carbon atoms, mono- or polycyclic cycloalkyl having 5-12 carbon atoms in which the carbon having the free valence is trisubstituted, monohydroxyalkyl, polyhydroxyalkyl, fluorine, chlorine, SH, SR.sub.6, SOR.sub.6, SO.sub.2 R.sub.6, alkenyl having 2-6 carbon atoms or alkenyloxy having 2 to 6 carbon atoms,
- R.sub.6 represents lower alkyl,
- R.sub.1 represents --COR.sub.7
- R.sub.7 represents hydrogen, OH, --OR.sub.10, --N(r'r"), monohydroxyalkyl, polyhydroxyalkyl or a sugar residue,
- R.sub.10 represents alkyl having 1-12 carbon atoms or alkenyl having 2-12 carbon atoms,
- r' and r", each independently, represent hydrogen, lower alkyl, aryl, aralkyl, an amino acid residue, a sugar residue, an amino sugar residue or a heterocycle, or r' and r" taken together form a heterocycle selected from the group consisting of piperidino, morpholino, pyrrolidino, piperazino and piperazino radical substituted at the 4-position with a C.sub.1 -C.sub.6 alkyl or a mono- or polyhydroxyalkyl radical,
- R.sub.2 represents hydrogen, OH, lower alkyl, alkoxy having 1-6 carbon atoms, fluorine, chlorine, CF.sub.3, COR.sub.7, CH.sub.2 OH or CH.sub.2 OR.sub.6 wherein R.sub.6 has the meaning given above,
- Z represents an oxygen atom, a sulphur atom, --CH.dbd.CR.sub.11 --, --N.dbd.CH-- or --N.dbd.CR.sub.6 -- wherein R.sub.6 has the meaning given above,
- R.sub.11 represents hydrogen, OH, lower alkyl, alkoxy having 1-6 carbon atoms, fluorine, chlorine or CF.sub.3,
- X represents a divalent radical which can be read from left to right or vice versa and has the formula ##STR18## wherein Q represents oxygen or --NR'--,
- R' represents a hydrogen atom or a --CH.sub.3 radical and
- Y represents oxygen or, alternatively Y represents sulphur when Q represents --NR'
- and the salts thereof when R.sub.1 represents a carboxylic acid function.
Dependencies are inferred from the claim text.