Pyrimidine compounds
AssigneeHoffmann-La Roche Inc.
InventorsThierry Godel, Claus Riemer
Life of this patent
Estimating the term…
Abstract
Compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 each individually are lower-alkyl or amino, A is ##STR2## B is hydrogen in A.sup.4, A.sup.5 and A.sup.6 ; ##STR3## in A.sup.1 -A.sup.6 ; lower-alkoxy in A.sup.4 -A.sup.6 ; and lower-alkyl, styryl, phenylethynyl or benzoyloxy-lower-alkyl in A.sup.1 and A.sup.2 ; n is 0, 1 or 2; m, p are, independently 0, 1 and R.sup.3, R.sup.4, R.sup.5 and R.sup.6 each independently are hydrogen, halogen, lower-alkyl, trifluoromethyl, lower-alkoxy or nitro, and pharmaceutically acceptable acid addition salts thereof. These compounds are useful in the control or prevention of illnesses which are caused by disorders of the dopamine system, in particular psychotic illnesses such as schizophrenia.
Claims16
A compound of the formula ##STR16## wherein B is ##STR17## lower-alkyl, styryl, phenylethynyl or benzoyloxy-lower-alkyl;
- R.sup.1 and R.sup.2 is independently, lower-alkyl or amino;
- R.sup.3 -R.sup.6 is independently, halogen, lower-alkyl, trifluoromethyl, lower-alkoxy or nitro;
- n is 0, 1 or 2, and
- m, p are, independently, 0 or 1.
A compound of the formula ##STR18## wherein B is ##STR19## R.sup.1 and R.sup.2 is independently, lower-alkyl or amino;
- R.sup.3 -R.sup.6 is independently, hydrogen, halogen, lower-alkyl, trifluoromethyl, lower-alkoxy or nitro;
- n is 0, 1 or 2, and
- m, p are, independently, 0 or 1.
A compound of the formula ##STR20## wherein B is hydrogen,
- or unsubstituted phenyl;
- R.sup.1 is methyl;
- R.sup.2 is amino.
A compound of the formula ##STR21## wherein R.sup.1 and R.sup.2 is lower-alkyl or amino.
A pharmaceutical composition comprising a compound of the formula ##STR22## wherein B is ##STR23## lower-alkyl, styryl, phenylethynyl or benzoyloxy-lower-alkyl;
- R.sup.1 and R.sup.2 is independently, lower-alkyl or amino;
- R.sup.3 -R.sup.6 is independently, halogen, lower-alkyl, trifluoromethyl, lower-alkoxy or nitro;
- n is 0, 1 or 2, and
- m, p are, independently, 0 or 1.
A pharmaceutical composition comprising a compound of the formula ##STR24## wherein B is ##STR25## R.sup.1 and R.sup.2 is independently, lower-alkyl or amino;
- R.sup.3 -R.sup.6 is independently, hydrogen, halogen, lower-alkyl, trifluoromethyl, lower-alkoxy or nitro;
- n is 0, 1 or 2, and
- m, p are, independently, 0 or 1.
A pharmaceutical composition comprising a compound of the formula ##STR26## wherein B is hydrogen,
- or unsubstituted phenyl;
- R.sup.1 is methyl;
- R.sup.2 is amino.
A pharmaceutical composition comprising a compound of the formula ##STR27## wherein R.sup.1 and R.sup.2 is lower-alkyl or amino.
Dependencies are inferred from the claim text.