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US 5,688,783 AGranted
Salinamides
AssigneeThe Regents of the University of California
InventorsWilliam H. Fenical, Robert S. Jacobs, Paul R. Jensen
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Abstract
Salinamides A and B are disclosed. These two bicyclic depsipeptides are produced by fermentation of a specific marine actinomycete, a Streptomyces sp, (CNB-091) in saltwater-based media. Salinamides A and B are useful as anti-biotic and anti-inflammatory agents.
Claims3
A method for treating mammals having inflamed tissue to reduce inflammation which comprises:
- administering to said mammal an inflammation reducing effective amount of a composition comprising a bicyclic depsipeptide selected from the group consisting of salinamide A and salinamide B wherein salinamide A has the structure ##STR5## and;
- wherein salinamide B has the structure ##STR6##
Dependencies are inferred from the claim text.