Medicaments for treating respiratory disorders
AssigneeGlaxo Group Limited
InventorsPhilip John Neale, Anthony James Taylor
Life of this patent
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Abstract
This invention relates to aerosol formulations of use for the administration of medicaments by inhalation, in particular a pharmaceutical aerosol formulation which comprises: (a) beclomethasone dipropionate monohydrate, the particle size of substantially all the monohydrate being less than 20 microns; (b) at least 0.015% by weight of the formulation of water in addition to the water of crystallization associated with the monohydrate; and (c) a fluorocarbon or hydrogen-containing chlorofluorocarbon propellant. A method of treating respiratory disorders which comprises administration by inhalation of an effective amount of a pharmaceutical aerosol formulation as defined is also described.
Claims18
A pharmaceutical aerosol formulation which comprises:
- (a) beclomethasone dipropionate monohydrate, the particle size of substantially all the monohydrate being less than 20 microns;
- (b) at least 0.015% by weight of the formulation of water in addition to the water of crystallisation associated with said monohydrate whereby said at least 0.015% water stabilizes the particle size of said beclomethasone dipropionate monohydrate particles;
- (c) a fluorocarbon or hydrogen-containing chlorofluorocarbon propellant.
A pharmaceutical aerosol formulation consisting essentially of particulate beclomethasone dipropionate monohydrate, at least 0.015% by weight of water and one or more fluorocarbon or hydrogen-containing chlorofluorocarbon propellant.
A method of treating respiratory disorders which comprises administration by inhalation of an effective amount of a pharmaceutical aerosol formulation which comprises:
- (a) beclomethasone dipropionate monohydrate, the particle size of substantially all the monohydrate being less than 20 microns;
- (b) at least 0.015% by weight of the formulation of water in addition to the water of crystallisation associated with said monohydrate whereby said at least 0.015% water stabilizes the particle size of said beclomethasone dipropionate monohydrate particles;
- (c) a fluorocarbon or hydrogen-containing chlorofluorocarbon propellant.
Dependencies are inferred from the claim text.