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AssigneesInstitute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v.z.w.
InventorsChoung Un Kim, John C. Martin, Bing Uh Luh, Peter F. Misco
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Provided are compounds of the following formulae: A phosphonomethoxymethyoxymethyl purine/pyrimidine derivative of the formula ##STR1## wherein X and X' are the same or different and are hydrogen or alkyl. R and R' are the same or different and are hydrogen, alkyl, hydroxyalkyl or alkanoyl; B is a purine or pyrimidine base. optionally R is taken together with X' to complete a cyclic phosphonate having the formula ##STR2## A 4'-phosphonomethoxytetrahydrofuranyl-1'-purine-pyrimidine of the formula ##STR3## wherein X and X' are the same or different and are hydrogen or alkyl, the dashed line is an optional bond, Y and Z are the same or different and are hydrogen, hydroxyl or alkyl or Y+Z are taken together to form an epoxide or cyclopropyl, and B is a purine or pyrimidine base.
A phosphonomethoxymethoxymethyl purine derivative of the formula I ##STR101## wherein X and X' are the same or different and are hydrogen or alkyl having 1 to 6 carbon atoms,
A method for treating a warm blooded animal infected with an HSV-1 virus, the method comprising administering to the warm blooded animal an antiviral effective amount of a phosphonomethoxymethoxymethyl purine derivative of the formula I ##STR104## wherein X and X' are the same or different and are hydrogen or alkyl having 1 to 6 carbon atoms,
Dependencies are inferred from the claim text.