Treatment of endotoxin-associated disorders with cationic peptides
AssigneeThe University of British Columbia
InventorsRobert E. W. Hancock, Kevin L. Piers, Melissa H. Brown, Niamh Kelly
Life of this patent
Estimating the term…
Abstract
A method for the microbial production of a cationic peptide having anti-microbial activity is provided, wherein the cationic peptide is first produced as a fusion protein having an anionic portion for suppressing the antimicrobial activity of the cationic portion. A novel cationic peptide having anti-microbial activity and LPS-binding activity is also provided. Such peptides are useful for suppressing the growth of bacteria and for the treatment of endotoxemia-associated disorders.
Claims6
A method of inhibiting the growth of bacteria comprising contacting the bacteria with an inhibiting effective amount of the peptide of Sequence ID No.24.
Dependencies are inferred from the claim text.