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US 5,688,765 AGranted
Ocular therapy in Sjogren's syndrome using topically applied androgensor TGF-.beta.
AssigneeThe Schepens Eye Research Institute, Inc.
InventorDavid A. Sullivan
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Abstract
The topical application to the ocular surface or adjacent regions of the eye of a preparation containing a therapeutic amount of an androgen or androgen analogue or a therapeutic amount of TGF-.beta. is disclosed as a method of relieving the chronic and acute manifestation of dry eye symptoms in Sjogren's syndrome. Measurement of the increased tear levels of TGF-.beta. is disclosed as a diagnostic test to monitor the therapeutic effect of topical treatment with androgen or androgen analogues.
Claims4
A method for treating keratoconjunctivitis sicca (KCS) comprising
- providing a therapeutic agent comprising a therapeutically effective amount of TGF-.beta. in a pharmaceutically acceptable carrier substance appropriate for ocular administration, and
- administering said therapeutic agent locally to the ocular surface or immediate vicinity of an eye of a patient suffering from said KCS.
Dependencies are inferred from the claim text.