Method of treating hypertension using animal stomach mucosa extract and endogenous protease-inhibitor peptides
OwnerZoltan W. Steinerinventor
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Abstract
A process of inhibiting the renin angiotensinogen angiotensin mechanism and treating hypertension administers a blood pressure lowering amount of a protease inhibitor peptide obtained by the cleavage of pepsinogen to a mammal. Hypertension is also treated by administering a blood pressure lowering amount of a stomach mucosa extract from animal origin. The extract is obtained under mild conditions in an extracting solvent containing an acidifying agent.
Claims18
A process for suppressing the formation of Angiotensin II in an animal comprising the steps of
- obtaining a protease-inhibitor peptide-containing extract, wherein said extract is obtained by forming a suspension of an animal stomach mucosa in an acidified solvent, precipitating proteins and recovering said inhibitor peptide-containing extract, said extract having a molecular weight of 10,754 and 101 amino acid residues per mole, and
- administering an effective amount of said protease-inhibitor peptide-containing extract to a mammal in need thereof to inhibit the renin-angiotensinogen-angiotensin enzymatic system and to suppress the formation of Angiotensin II.
A process for suppressing the formation of Angiotensin II within a mammal, the process comprising the step of
- administering an effective amount of a pepsin-inhibitor-peptide to said mammal to inhibit the renin-angiotensinogen-angiotensin mechanism in said animal and to suppress formation of Angiotensin II, wherein said pepsin-inhibitor peptide has 29 amino acid residues and a molecular weight of about 3242.
Dependencies are inferred from the claim text.