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US 5,688,697 AGranted
Stabilized microspheres and methods of preparation
AssigneeBecton, Dickinson and Company
InventorsAdrien Malick, Hans H. Feindt, Gerald D. Hahn
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Abstract
Stabilized microspherical particles having hydrophobic liquid cores prepared as oil-in-water microemulsions. The particles are stabilized by a surface layer comprising an amphiphilic compound and may be functionalized to allow covalent coupling of a ligand to the surface of the particle. When used as tracers in assays, a water insoluble dye may be incorporated in the core liquid of the microparticles.
Claims15
A method of making functionalized microspherical particles comprising:
- a) preparing a solvent solution comprising a water miscible organic solvent, a liquid silicone compound and an amphiphilic ligand, and;
- b) combining said solvent solution with an aqueous medium to form an oil-in-water microemulsion having as the dispersed phase microspherical particles comprising a liquid silicone core and a monolayer on the surface of the core comprising the amphiphilic ligand.
A method of making microspherical particles comprising:
- a) preparing a solvent solution comprising a water miscible organic solvent, a liquid silicone compound and an amphiphilic compound, and;
- b) combining said solvent solution with an aqueous medium to form an oil-in-water microemulsion having as the dispersed phase microspherical particles comprising a core, the core comprising the liquid silicone compound, and a monolayer on the surface of the core comprising the amphiphilic compound, and;
- c) isolating the microspherical particles.
Dependencies are inferred from the claim text.