Monoclonal antibodies to human leukemia inhibitory factor
AssigneeGenentech, Inc.
InventorKyung Jin Kim
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Abstract
The invention relates to monoclonal antibodies to human leukemia inhibitory factor. The disclosed monoclonal antibodies are believed to recognize unique epitopes on hLIF and are useful in the treatment of conditions wherein the presence of hLIF causes or contributes to undesirable pathological effects, such as cachexia, dysregulated calcium metabolism, or excessive bone cell proliferation, and in the detection of hLIF, for example, in clinical samples or specimens.
Claims13
A monoclonal antibody that specifically binds human LIF and neutralizes a biological activity of human LIF.
The hybridoma cell deposited under American Type Culture Collection Accession Number ATCC HB 11077.
The hybridoma cell deposited under American Type Culture Collection Accession Number ATCC HB 11074.
The hybridoma cell deposited under American Type Culture Collection Accession Number ATCC HB 11075.
Dependencies are inferred from the claim text.