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US 5,688,526 AGranted
Hemoglobin-encapsulating liposome and method for making the same
AssigneeTerumo Kabushiki Kaisha
InventorsTakeshi Okamoto, Hiroshi Goto
Life of this patent
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Abstract
A hemoglobin-encapsulating liposome having encapsulated thererin a hemoglobin solution having added thereto a substrate for an enzymatic reaction which produces reduced-form nicotinamide adenine dinucleotide (NADH) and/or reduced-form nicotinamide adenine dinucleotide phosphate (NADPH). Irreversible oxidation of hemoglobin with lapse of time is markedly suppressed.
Claims7
A hemoglobin-encapsulating liposome comprising
- a liposome comprising a lipid,
- a hemoglobin-containing solution encapsulated in said liposome, wherein said hemoglobin-containing solution is a concentrated stroma free hemoglobin solution derived from natural erythrocyte, and
- at least one further added material selected from the group consisting of malic acid, oxaloacetic acid, citric acid, isocitric acid, .alpha.-ketoglutaric acid, succinyl-CoA, succinic acid, fumaric acid, aspartic acid, pyruvic acid, phosphoenolpyruvic acid, acetyl-CoA, and glutamic acid in an amount sufficient to suppress hemoglobin oxidation.
Dependencies are inferred from the claim text.