Lactulose pastilles
AssigneeBolder Arzneimittel GmbH
InventorsHermann-Josef Bolder, Faruk Imer
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Abstract
Object of the invention is a single dose form of application for lactulose in the form of pastilles based on at least partially or completely water soluble natural and/or synthetic polymers selected from gums, alginates, carrageen, starch, pectin, and gelatin comprising lactulose as active substance, as well as a process to prepare the said pastilles.
Claims11
Sucking pastilles comprising, based on from 2 to 80% by weight, based on the total mass of the pastilles, at least partially or completely water soluble natural polymers, synthetic polymers, or both selected from the group consisting of gums, alginates, carrageen, starch, pectin, and gelatin which polymers are suitable to form gels or viscous solutions in aqueous systems, and sugar substitutes selected from the group consisting of fructose, sorbitol, mannitol, xylitol, hydrogenated glucose syrup, and sweeteners, and the pastilles further comprising 4-O-.beta.-D-galactopyranosyl-D-fructose (lactulose) as an active substance.
Process for the preparation of sucking pastilles having;
- based on from 2 to 80% by weight;
- based on the total mass of the pastilles;
- at least partially or completely water soluble natural polymers;
- synthetic polymers, or both, which polymers are suitable to form gels or viscous solutions in aqueous systems, and additional adjuvants and additives, and 4-O-.beta.-D-galaetopyranosyl-D-fructose (lactulose) as an active substance, comprising
- a) contacting at least partially or completely water soluble natural, synthetic polymers, or both selected from the group consisting of gums, alginates, carrageen, starch, pectin, and gelatin, with water and sugar subsitutes selected from the group consisting of fructose, sorbitol, mannitol, xylitol, hydrogenated glucose syrup, and sweeteners to form a gel or a viscous solution, and emulsifying, suspending, or dissolving lactulose in the gel or viscous solution,
- b) the gel or viscous solution is cast into forms, to form the pastilles and
- c) the pastilles are dried at room temperature or elevated temperature.
Dependencies are inferred from the claim text.