Flash-flow fused medicinal implants
OwnerRobert J. Leonardinventor
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Abstract
A totally-fused pellet and a process and a device for preparing the totally-fused pellet are provided. Conditions are applied to the pelleting material to melt the material uniformly such that the phase transition of all of the material occurs approximately simultaneously. The material is removed from the melting conditions immediately upon the melting of the material and the material is subjected immediately to cooling conditions. The resulting totally-fused pellet contains no thermal degradation impurities.
Claims24
A totally-fused pellet capable of sustained-release of a steroid drug comprising,
- a melted and recrystallized steroid drug free of a carrier combined therewith, said pellet characterized by the absence of thermal degradation impurities caused by overexposing said steroid drug to heat when melting said steroid drug.
A pellet capable of sustained release of a steroid drug consisting of a completely melted and recrystallized steroid drug.
A pellet for sustained release of a drug, said pellet including a completely melted steroid drug free of carrier combined therewith, said pellet produced by:
- isotropically melting asteroid drug to form a liquid under conditions in which phase transition from solid to liquid occurs simultaneously for all material in said pellet;
- and
- cooling said melted drug to allow recrystallization thereof, said pellet characterized by the absence of thermal degradation impurities caused by overexposing said steroid drug to heat.
A pellet for sustained release of a drug, said pellet comprising 85% by weight norethindrone and 15% by weight cholesterol, the pellet produced by:
- isotropically melting said norethindrone and cholesterol to form a liquid in which phase transition from solid to liquid occurs simultaneously for all material in the pellet;
- and
- cooling said melted norethindrone and cholesterol to allow simultaneous recrystallization thereof to form a fused matrix, said pellet characterized by absence of thermal degradation impurities caused by overexposing said norethindrone to heat.
Dependencies are inferred from the claim text.