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OwnerFrancesco Blasi, Maria Patrizia Stoppelli +3inventors
InventorsFrancesco Blasi, Maria Patrizia Stoppelli, Maria Rosaria Mastronicola, Karen Gjersing Welinder, Isabel Correas
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Phosphorylated plasminogen activator, such as phosphorylated pro-urokinase (pro-u-PA), which is substantially free from unphosphorylated plasminogen activator, may be obtained by phosphorylating unphosphorylated plasminogen activator with a phosphorylating enzyme or by separating phosphorylated plasminogen activator from a mixture of phosphorylated plasminogen activator and unphosphorylated plasminogen activator. Phosphorylated pro-u-PA, which is substantially free from unphosphorylated pro-u-PA, is converted by plasmin into phosphorylated u-PA. The phosphorylated plasminogen activators such as phosphorylated pro-u-PA, u-PA and t-PA are useful as thrombolytic agents.
Isolated and purified phosphorylated pro-u-PA which is substantially free from unphosphorylated pro-u-PA.
Isolated and purified phosphorylated u-PA, which is substantially free from unphosphorylated u-PA.
A pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and, as the active ingredient, phosphorylated u-PA or pro-u-PA or combinations thereof, which are substantially free from unphosphorylated u-PA or pro-u-PA.
A method of thrombolytic therapy in a patient, which method comprises administering to a patient in need of it an effective amount of phosphorylated u-PA or pro-u-PA or combinations thereof, which are substantially free from unphosphorylated u-PA or pro-u-PA.
Dependencies are inferred from the claim text.