Antagonism of endothelin actions
AssigneeQueen's University at Kingston
InventorsJames D. Banting, Jeremy P.W. Heaton, Michael A. Adams
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Abstract
The mechanism of hypertension following acute NO synthase blockade is via endothelin mediated vasoconstriction. Thus, NO appears to inhibit endothelin activity by blocking its expression and not as a chronic direct acting vasodilator. Administration of an endothelin antagonist to a patient in a `normal` physiological state may result in specific regional vasodilation. This treatment finds utility in the treatment of erectile dysfunction.
Claims10
A method for down regulating local endothelin-mediated erectile dysfunction in a patient independently of any normal or abnormal systemic physiology comprising:
- administering an effective amount of endothelin antagonist agent in a pharmaceutically acceptable carrier therefor.
Dependencies are inferred from the claim text.