Use of fullerenes in diagnostic and/or therapeutic agents
AssigneeNycomed Salutar, Inc.
InventorsAlan D. Watson, Jo Klaveness, Gene C. Jamieson, Jere D. Fellmann, Nils B. Vogt
Life of this patent
Estimating the term…
Abstract
Compounds including tight molecular meshes, preferably curved in one or two directions, such as fullerenes and met-cars, can be used as carriers for diagnostic or therapeutic agents, especially diagnostic contrast agents.
Claims35
A compound comprising a curved or planar molecular mesh structure in the skeleton of which essentially all mesh aperture ring atoms are branching sites, said compound being externally linked to a metal or metal complex coordinating chelant group, or a conjugate, intercalate, inclusion compound or salt thereof, for use as a diagnostic or therapeutic agent.
A compound comprising a curved or planar molecular mesh structure in the skeleton of which essentially all mesh aperture ring atoms are branching sites, said compound being externally linked to a metal or metal complex coordinating chelant group, or a conjugate, intercalate, inclusion compound or salt thereof, for use as a diagnostic or therapeutic agent, said compound being of formula I
- R.sub.2.sbsb.n @R.sub.3.sbsb.m R.sub.4.sbsb.n' (I)
- (where n and n' are zero or positive integers;
- m is an integer having a value of at least 20;
- @R.sub.3m is a closed curbed met-car, fullerene, faux fullerene or fulleroid formed from m mesh aperture ring atoms R.sub.3 which may be the same or different;
- each R.sub.2 which may be the same or different is a mono or polyatomic species entrapped within the @R.sub.3m cage;
- and each R.sub.4 which may be the same or different is a mono or polyatomic species covalently bound to the @R.sub.3 m cage) or a salt thereof, wherein at least one R.sub.2 is present which is a transition or lanthanide metal and at least one R.sub.4 is present which is a halogen atom.
A compound comprising a curved or planar molecular mesh structure in the skeleton of which essentially all mesh aperture ring atoms are branching sites, said compound being externally linked to a metal or metal complex coordinating chelant group, or a conjugate, intercalate, inclusion compound or salt thereof, for use as a diagnostic or therapeutic agent, comprising a metallo-carbohedrane or a derivative thereof.
A compound comprising a curved or planar molecular mesh structure in the skeleton of which essentially all mesh aperture ring atoms are branching sites, said compound being externally linked to a metal or metal complex coordinating chelant group, or a conjugate, intercalate, inclusion compound or salt thereof, for use as a diagnostic or therapeutic agent, comprising a Gd encapsulating molecular mesh structure.
A compound comprising a curved or planar molecular mesh structure in the skeleton of which essentially all mesh aperture ring atoms are branching sites, said compound being externally linked to a metal or metal complex coordinating chelant group, or a conjugate, intercalate, inclusion compound or salt thereof, for use as a diagnostic or therapeutic agent, comprising at least one curved molecular mesh structure linked to a metal or metal complex coordinating chelant group.
A compound comprising a curved or planar molecular mesh structure in the skeleton of which essentially all mesh aperture ring atoms are branching sites, said compound being externally linked to a metal or metal complex coordinating chelant group, or a conjugate, intercalate, inclusion compound or salt thereof, for use as a diagnostic imaging contrast agent.
A diagnostic composition comprising a sterile pharmaceutically acceptable carrier or excipient together with an image contrast enhancing physiologically tolerable compound comprising a curved or planar molecular mesh structure in the skeleton of which essentially all mesh aperture ring atoms are branching sites, said compound being externally linked to a metal or metal complex coordinating chelant group, or a conjugate, intercalate, inclusion compound or salt thereof.
A pharmaceutical composition comprising a sterile pharmaceutically acceptable carrier or excipient together with a therapeutically effective compound comprising a curved molecular mesh structure in the skeleton of which essentially all mesh aperture ring atoms are branching sites, said compound being externally linked to a metal or metal complex coordinating chelant group, or a conjugate, intercalate, inclusion compound or salt thereof.
A composition comprising a sterile pharmaceutically acceptable carrier or excipient together with a therapeutically effective compound comprising a curved molecular mesh structure in the skeleton of which essentially all mesh aperture ring atoms are branching sites, said compound being externally linked to a metal or metal complex coordinating chelant group, or a conjugate, intercalate, inclusion compound or salt thereof wherein said compound contains a therapeutically effective metal.
A method of imaging of a subject comprising:
- introducing into said subject a compound comprising a curved or planar molecular mesh structure in the skeleton or which essentially all mesh aperture ring atoms are branching sites, said compound being externally linked to a metal or metal complex coordinating chelant group, or a conjugate, intercalate, inclusion compound or salt thereof, which compound contains a moiety capable of modifying image contrast in an imaging modality;
- and generating an image of at least part of said subject by said imaging modality.
A method of treatment of a condition responsive to radiotherapy or metal ion therapy, said method comprising administering to a subject a therapeutically effective amount of physiologically tolerable compound comprising a curved or planar molecular mesh structure in the skeleton of which essentially all ring atoms are branching sites, said compound being externally linked to a metal or metal complex coordinating chelant group, said compound comprising at least one atom of a therapeutically effective metal or radioisotope.
A medical apparatus characterized in that at least a portion of the apparatus incorporates or is coated with a curved molecular mesh structure compound comprising a diagnostically or therapeutically effective entity and in the mesh skeleton of which essentially all mesh aperture ring atoms are branching sites, said compound being externally linked to a metal or metal complex coordinating chelant group, or a conjugate, intercalate, inclusion compound or salt thereof.
Dependencies are inferred from the claim text.