Electronincorporation enhanced transdermal delivery of molecules
AssigneeGenetronics, Inc.
InventorsGunter A. Hofmann, Lei Zhang
Life of this patent
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Abstract
A method of transdermal molecular delivery comprising molecules to be delivered mixed with particles, contacting a selected area of a skin surface with the particles and molecules, applying a pulsed electric field of sufficient amplitude and duration to induce dielectric breakdown of the stratum corneum, and applying a pressure to the molecules to force transport of the molecules through the pores in the stratum corneum into the underlying skin.
Claims28
A method of transdermal molecular delivery comprising the steps of:
- providing molecules to be delivered through a stratum corneum;
- providing a solution containing particles and said molecules;
- contacting a selected surface area of the stratum corneum with said solution;
- applying a pulsed electric field of sufficient amplitude to induce pores in the stratum corneum;
- and
- applying a force to said molecules sufficient to induce transport of said molecules through the induced pores in the stratum corneum.
A method according to claim 4 wherein said force is a vacuum.
A method of transdermal molecular delivery comprising the steps of:
- contacting a selected surface area of a stratum corneum with a quantity of molecules to be delivered through the stratum corneum;
- applying a pulsed electric field of sufficient amplitude to induce pores in the stratum corneum;
- and
- applying a force to said molecules sufficient to induce transport of said molecules through the induced pores in the stratum corneum wherein said force is a vacuum.
A method of transdermal molecular delivery comprising the steps of:
- contacting a selected surface area of the stratum corneum with a quantity of molecules to be delivered through a stratum corneum;
- applying a pulsed electric field of sufficient amplitude to induce pores in the stratum corneum, said electric field is applied by means of a plurality of closely spaced electrodes applied to the surface of the stratum corneum and is applied as pulses of from 10 to several hundred volts with a pulse length of between 10 .mu.sec to 100 msec;
- and
- applying a force to said molecules sufficient to induce transport of said fluid through the pores in the stratum corneum wherein said pressure is applied by pressurized fluid carrying said molecules.
A method of transdermal molecular delivery comprising the steps of:
- incorporating molecules to be delivered in a carrier containing particles;
- contacting a selected area of a stratum corneum with said carrier of the molecules;
- applying a pulsed electric field of sufficient amplitude and duration to induce pores by dielectric breakdown of the stratum corneum;
- and applying a pressure to the molecules to force transport of the molecules through the induced pores in the stratum corneum into underlying tissue.
Dependencies are inferred from the claim text.