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US 5,687,920 AGranted
Apparatus for the continuous milling of aerosol pharmaceutical formulations in aerosol propellants
AssigneeAbbott Laboratories
InventorsAkwete L. Adjei, Dennis Y. Lee, Anthony J. Hlinak
Life of this patent
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Abstract
The present invention provides a process and apparatus for the continuous milling of aerosol pharmaceutical formulations which contain solids by milling in the aerosol propellant.
Claims3
An apparatus for continuous milling of aerosol pharmaceutical formulations in an aerosol propellant comprising
- a) a first supply tank having cooling means for holding a supply of aerosol pharmaceutical formulation and magnetic stirrers located inside;
- b) a second receiving tank having cooling means and magnetic stirrers located inside;
- c) a bead milling apparatus interconnected between said supply and receiving tanks for reducing the solid particle size of said aerosol pharmaceutical formulation;
- d) means for continuous in-stream monitoring of solids particle size;
- e) pump means for reversibly passing said aerosol pharmaceutical formulation from said first supply tank through said particle size analyzer and said milling apparatus to said second receiving tank and return;
- and
- f) refrigeration means for circulating a coolant through the cooling means of said first supply and said second receiving tank.
4 more elements
Dependencies are inferred from the claim text.