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US 5,687,746 AGranted
Dry powder delivery system
AssigneesAdvanced Therapeutic Products, Inc., Duke University
InventorsJed E. Rose, Frederique Behm, James Turner
Life of this patent
Estimating the term…
Abstract
A dry powder delivery system having an elongated tube containing a matrix having a measured mount of dry particles of therapeutic compound and a porous element having a desiccant therein is disclosed. The porous element with the desiccant can be combined with the powder-containing matrix or it can be two separate elements. The pressure drop induced by inhalation of the user causes air to flow through the tube and into contact with the particles of dry powder for discharging the particles for inhalation by the user.
Claims24
A dry powder delivery system comprising:
- (a) an elongated tubular housing having proximal and distal ends and a passageway for air flow between the ends;
- (b) the distal end having at least one inlet opening through which air can be introduced into the passageway;
- (c) the proximal end forming a mouth piece with at least one end outlet opening through which air can be withdrawn from the passageway;
- (d) a resistance member that creates a controlled pressure drop between the distal and proximal ends and a resistance to the drawing of air at the mouth piece, said resistance being sufficiently great that particles are drawn into the mouth of the user to simulate the action of puffing on a cigarette;
- (e) means for introducing a measured mount of particles of a dry powder compound having a therapeutic capability into air flowing in a flow path in the passageway so that said particles will travel downstream from the resistance member whereby suction created at the proximal end causes air to flow in the passageway and into contact with particles of said dry powder for discharge through the outlet at a low velocity;
- (f) the particles being sized and coordinated with the controlled pressure drop so the particles can be drawn into the mouth of the user and inhaled;
- (g) wherein the means for introducing a measured amount of particles includes a matrix with a plurality of passageways in the flow path, the passageways containing the dry powder.
4 more elements
A dry powder delivery system comprising:
- (a) an elongated tubular housing having proximal and distal ends and a passageway for air flow between the ends;
- (b) the distal end having at least one inlet opening through which air can be introduced into the passageway;
- (c) the proximal end forming a mouth piece with at least one end outlet opening through which air can be withdrawn from the passageway;
- (d) a resistance member that creates a controlled pressure drop between the distal and proximal ends and a resistance to the drawing of air at the mouth piece, said resistance being sufficiently great that the particles are drawn into the mouth of the user to simulate the action of puffing on a cigarette;
- (e) means for introducing a measured amount of particles of a dry powder compound having a therapeutic capability into air flowing in a flow path in the passageway so that said particles will travel downstream from the resistance member whereby suction created at the proximal end causes air to flow in the passageway and into contact with particles of said dry powder for discharge through the outlet at a low velocity;
- (f) the proximal end of the tubular housing including an inner tube, with a space between the housing and the inner tube, and thread means between the housing and the inner tube for introducing measured mounts of dry powder into the flow path as the inner tube is rotated relative to the housing;
- and
- (g) the particles being sized and coordinated with the controlled pressure drop so the particles can be drawn into the mouth of the user and inhaled.
5 more elements
A dry powder delivery system comprising:
- (a) an elongated tubular housing having proximal and distal ends and a passageway for air flow between the ends;
- (b) the distal end having at least one inlet opening through which air can be introduced into the passageway;
- (c) the proximal end forming a mouth piece with at least one end outlet opening through which air can be withdrawn from the passageway;
- (d) a resistance member that creates a controlled pressure drop between the distal and proximal ends and a resistance to the drawing of air at the mouth piece, said resistance being sufficiently great that the particles are dram into the mouth of the user to simulate the action of puffing on a cigarette;
- (e) means for introducing a measured mount of particles of a dry powder compound having a therapeutic capability into air flowing in a flow path in the passageway so that said particles will travel downstream from the resistance member whereby suction created at the proximal end causes air to flow in the passageway and into contact with particles of said dry powder for discharge through the outlet at a low velocity;
- (f) the tubular housing including a plurality of bristle elements mounted on an inner surface of the housing, said bristles being charged with dry powder and a scraper mounted at the proximal end of the housing for sequentially scraping the bristles for dislodging and introducing the measured amount of dry powder into the flow path;
- and
- (g) the particles being sized and coordinated with the controlled pressure drop so the particles can be drawn into the mouth of the user and inhaled.
5 more elements
Dependencies are inferred from the claim text.