Back to results
US 5,686,634 AGranted
Process for producing 5-hydroxy-6-demethyl-6-desoxy-6-methylene-11A-chlorotetracycline
AssigneePfizer Inc.
InventorsWolfgang Kruger, Gisela Kruger
Life of this patent
Estimating the term…
Abstract
In a process for dehydrating 5-hydroxy-11a-chlorotetracycline-6,12-hemiketal to 5-hydroxy-6-demethyl-6-desoxy-6-methylene-11a-chlorotetracycline, utilizing an acid which is not decomposable by water, formic acid serves as a solvent free from chlorinated hydrocarbons.
Claims7
A process for the preparation of 5-hydroxy-6-demethyl-6-desoxy-6-methylene-11a-chlorotetracycline which comprises treating 5-hydroxy-11a-chlorotetracycline-6,12hemiketal, in the absence of a diluent or any material which will react with water, with a dehydrating solution consisting of sulfuric acid, as dehydrating agent, and formic acid, as solvent.
Dependencies are inferred from the claim text.