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US 5,686,629 AGranted
Method and cyclic carbonates for nucleotide analogues
AssigneeGilead Sciences, Inc.
InventorsNorbert W. Bischofberger, Kenneth M. Kent
Life of this patent
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Abstract
An improved method for the preparation of acyclic nucleotide analogues comprises first condensing a cyclic carbonate with a purine or pyrimidine base and then reacting the alkylated base with an activated phosphonate. Novel cyclic carbonates are employed to yield the desired phosphonylmethoxyalkyl nucleotide analogues.
Claims6
A compound having the structure I ##STR9## wherein R.sup.1 is --CH.sub.2 N.sub.3, --(CH.sub.2).sub.2 N.sub.3, or --CH.sub.2 NH.sub.2.
Dependencies are inferred from the claim text.