Substituted hydrindanes for the treatment of angiogenesis-dependent diseases

A substituted hydrindane having the formula ##STR7## where X is C(OH)R.sub.1 R.sub.1, C(OR.sub.1)R.sub.1 R.sub.1, C(OR.sub.2)R.sub.1 R.sub.1, C(OH)R.sub.1 R.sub.2, C(OR.sub.1)R.sub.1 R.sub.2, C(OR.sub.2)R.sub.1 R.sub.2, C(OH)R.sub.2 R.sub.2, C(OR.sub.1)R.sub.2 R.sub.2, C(OR.sub.2)R.sub.2 R.sub.2, S(.dbd.O).sub.n H, S(.dbd.O).sub.n R.sub.1, SR.sub.2, P(.dbd.O)R.sub.1 R.sub.1, P(.dbd.O)(OH).sub.2, P(.dbd.O)(OH)(OR.sub.1), P(.dbd.O)(OR.sub.1)(OR.sub.1), P(.dbd.O)(OH)(NH.sub.2), P(.dbd.O)(OR.sub.1)(NH.sub.2), P(.dbd.O)(OH)(NHR.sub.1), P(.dbd.O)(OH)(NR.sub.1 R.sub.1), P(.dbd.O)(OR.sub.1)(NHR.sub.1) P(.dbd.O)(OR.sub.1)(NR.sub.1 R.sub.1), NH.sub.2, NHR.sub.1, NHR.sub.2, NR.sub.1 R.sub.1, NR.sub.1 R.sub.2, NHOH, N(OH)R.sub.1, N(OH)R.sub.2, NH(OR.sub.1), NH(OR.sub.2), N(OR.sub.1)R.sub.2, N(OR.sub.2)R.sub.1, N(OR.sub.2)R.sub.2, N(OR.sub.1)R.sub.1, .sup..sym. S(R.sub.1)(.sub.1) Q.sup..sym., .sup..sym. N(R.sub.1)R.sub.1)(R.sub.1) Q.sup..sym. wherein Q.sup..sym. is a halide, sulfonate, or carboxylate anion;

• C(.dbd.O)R.sub.1, C(.dbd.O)R.sub.2, C(.dbd.O)NH.sub.2, C(.dbd.O)NHR.sub.1, C(.dbd.O)NR.sub.1 R.sub.1, C(.dbd.O)N(OH)R.sub.1, C(.dbd.O)N(OR.sub.1)OR.sub.1, C(.dbd.O)N(OR.sub.2)R.sub.1 ;
• n=0, 1 or2;
• R.sub.1 is aryl, haloaryl, C.sub.1 -C.sub.10 alkyl, branched alkyl, cycloalkyl, aralkyl, carboxyalkyl or haloalkyl, optionally unsaturated and/or substituted with up to 6 OH, 6 OR.sub.3, or 6 OR.sub.2 ;
• or imidazolyl, triazolyl, thiadiazolyl, oxadiazolyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, or pyridyl, optionally substituted with up to three halogen or C.sub.1 -C.sub.6 alkyl groups;
• R.sub.2 is C(.dbd.O)H, C(.dbd.O)R.sub.1, C(.dbd.O)OR.sub.1, C(.dbd.O)OH, C(.dbd.O)NH.sub.2 C(.dbd.O)NHR.sub.1, C(.dbd.O)NR.sub.1 R.sub.1 ;
• R.sub.3 is aryl, haloaryl, C.sub.1 -C.sub.10 alkyl, branched alkyl, cycloalkyl, aralkyl, carboxyalkyl or haloalkyl optionally unsaturated and/or substituted with up to 6 OH;
• R.sub.4 is H, OR.sub.2, OR.sub.1, OH, .dbd.NOH, .dbd.NOR.sub.1, .dbd.NOR.sub.2 ;
• and provided that if X is S(O).sub.2 (optionally substituted phenyl) then R.sub.4 .noteq.OH;
• and
• R.sub.7 and R.sub.8 are H or together are optionally a double bond;
• and wherein aryl denotes phenyl, naphthyl, furyl, thienyl, pyridyl, benzofuryl, indolyl, benzothienyl, quinolyl or isoquinolyl;
• R.sub.1 R.sub.1 attached to the same C, S, P or N atom can form a ring of from 3 through 7 members;
• and for those substituents containing more than one R.sub.1, R.sub.2 or R.sub.3, each R.sub.1, R.sub.2, or R.sub.3 may be the same or different;
• or a pharmaceutically acceptable salt or ester thereof.