Process for preparing an optically active amine
AssigneeTakasago International Corporation
InventorsKazuhide Tani, Tsuneaki Yamagata, Yasutaka Kataoka, Hidenori Kumobayashi
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Abstract
A novel process for preparing an optically active amine by asymmetric hydrogenation of an imine compound, such as an imine compound prepared by condensing benzylamine and acetophenone, in the presence of a catalytic amount of an iridium-optically active phosphine complex and benzylamine or a benzylamine derivative. The present invention provides an optically active amine of high optical purity.
Claims17
A process for preparing an optically active amine compound which comprises asymmetrically hydrogenating an imine compound having the following general formula (I) ##STR8## wherein R.sup.1, R.sup.2 and R.sup.3 each represents an aromatic hydrocarbon group, an aliphatic hydrocarbon group or an alicyclic hydrocarbon group, and two of R.sup.1, R.sup.2 and R.sup.3 may bond together to form a 5- or 6-membered ring in the presence of a catalytic amount of an iridium-optically active phosphine complex and benzylamine or a benzylamine derivative.
A process for preparing an optically active amine compound which comprises asymmetrically hydrogenating an imine compound having the following general formula (I) ##STR12## wherein R.sup.1, R.sup.2 and R.sup.3 each represents (i) an aromatic hydrocarbon group which may be substituted with a halogen atom, a lower alkyl group or a lower alkoxy group, (ii) an aliphatic hydrocarbon group which may be substituted with a halogen atom, a lower alkyl group, a lower alkoxy group or said aromatic hydrocarbon group, or (iii) an alicyclic hydrocarbon group which may be substituted with a halogen atom, a lower alkyl group, a lower alkoxy group or said aromatic hydrocarbon group, and two of R.sup.1, R.sup.2 and R.sup.3 may bond together to form a 5- or 6-membered ring in the presence of a catalytic amount of an iridium-optically active phosphine complex and benzylamine or a benzylamine derivative.
Dependencies are inferred from the claim text.