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US 5,686,607 AGranted
Pyridyl ethylation of lactam derivatives
AssigneeMerck & Co., Inc.
InventorsJohn Y. L. Chung, Dalian Zhao, David J. Mathre
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Abstract
The invention is a highly efficient synthesis for making compounds of formula (iv) wherein R is C.sub.1-4 alkyl or benzyl; and R.sup.1, when present, is C.sub.1-4 alkyl, OH, O--C.sub.1-4 alkyl, or S--C.sub.1-4 alkyl; which are useful intermediates for making compounds such as those represented in formula (I). ##STR1##
Claims5
A process for preparing compounds having the formula ##STR42## wherein R is C.sub.1-4 alkyl or benzyl;
- and
- R.sup.1, when present, is C.sub.1-4 alkyl, OH, O--C.sub.1-4 alkyl, or S--C.sub.1-4 alkyl;
- which comprises
- a) dissolving a compound having the formula ##STR43## wherein R.sup.1, when present, is C.sub.1-4 alkyl, OH, O--C.sub.1-4 alkyl, or S--C.sub.1-4 alkyl;
- and
- R.sup.8 is C.sub.1-4 alkyl;
- in an anhydrous alcohol solution comprising 4-vinylpyridine to form ##STR44## b) decarboxylating the compound ##STR45## to form ##STR46## c) alkylating iii to form ##STR47##
4 more elements
Dependencies are inferred from the claim text.